In vitro Modulation of Canine Polymorphonuclear Leukocyte Function by Granulocyte-Macrophage Colony Stimulating Factor. (Reannouncement with New Availability Information).

摘要

T lymphocyte derived granulocyte-macrophage colony stimulating factor (GMCSF) reportedly demonstrates numerous inflammatory bioregulatory properties. The 22 Kd glycoprotein inhibits polymorphonuclear leukocyte (PMN) migration, stimulates phagocytosis of bacteria, and primes PMNs for enhanced oxidative responses to fmlp, LTB4, or C5a desArg. In addition to GMCSF, endotoxin, low levels of fmlp, and B-cell derived factor also prime PMNs for enhanced oxidative responses, suggesting the possibility of multiple priming mechanisms. Priming may enhance normal oxidative burst levels to those necessary for a competent response during an inflammatory event. Exogenous administration of GMCSF stimulates macrophage, granulocyte, and eosinophil colony formation in human bone marrow cell culture and granulocyte, macrophage, erythroid, and mixed colonies in nonhuman primates.