Adaptive Nulling in the Hyperthermia Treatment of Cancer. (Reannouncement withNew Availability Information)

摘要

We have investigated the use of adaptive array antenna techniques to maximize theapplied electric field at a tumor site in a target body while simultaneously minimizing or reducing the field at the locations of undesired high-temperature regions, or hot spots. Computer simulations have shown that adaptive nulling can prevent undesired hot spots from occurring during the heating of a deep-seated tumor. The simulation results have been supported by experimental measurements with a commercial hyperthermia phased-array antenna system that was modified to implement adaptive-nulling and adaptive-focusing algorithms. The experiments were conducted at the State University of New York (SUNY) Health Science Center in Syracuse, N.Y. Two types of phantom targets-a saline-filled polyethylene bottle and a beef sample-were used in the experiments. Results indicate that adaptive nulling can be used to reduce the electric field at one or more target positions while simultaneously maintaining a focus at a deep-seated location within the target.... Adaptive nulling, Adaptive focusing, Hyperthermia, Tumor-heating, Cancer therapy.