Quantitative Structure-Activity Analysis of Acetylcholinesterase Inhibition byOxono and Thiono Analogues of Organophosphorus Compounds

摘要

A comparison of the bimolecular rate constants (ki) for inhibition of electriceel acetylcholinesterase (AChE) by the oxono (i.e., P=O) and thiono (i.e., P=S) analogues of parathion, methylparathion, leptophos, fonofos, sarin, and soman revealed that the oxono/thiono ratios of ki values varied from 14 for soman to 1240 for parathion. Analysis of the relative importance of the dissociation equilibrium constant and the phosphorylation rate constant in producing this variation in ki values indicated that the oxono analogues had phosphorylation