Hydrogen Bonding. 30. Solubility of Gases and Vapors in Biological Liquids andTissues

摘要

The general solvation equation log L = C + rR2 + s pi H sub 2 + a alpha H sub 2 +b beta H sub 2 I logL16 has been used to analyze the solubility of solute gases and vapors, as log L values, in water, blood, and a variety of other biological fluids and tissues. The explanatory variables are R2, the solute excess molar refraction; pi H sub 2, the solute dipolarity/polarizability; alpha H sub 2 and beta H sub 2, the solute hydrogen-bond acidity and basicity; and log L16, where L16 is the solute Ostwald solubility coefficient of hexadecane. The obtained coefficients then serve to characterize the biological phase as follows: r + s is