Autoradiographic Distribution and Applied Pharmacological Characteristics ofDextromethorphan and Related Antitissue/ Anticonvuleant Drugs and Novel Analogs

摘要

Relief of pain has always been one of the great objectives in medicine, and inthis regard morphine has been for a long time an invaluable tool in the hand of the practitioner. However, the severe side effects with which this substance is endowed have often limited its use. This explains why such an effort was made during the first half of the century in the synthesis of new derivatives that could have been capable of exerting an analgesic effect comparable to that of morphine without side effects such as addiction liability, respiratory depression, or toxicity. Modifications of morphine's polycyclic structure have led to one of tke first series of structure-activity relationship for this class of substances and to a high number of derivatives with different degrees of selectivity for different opioids receptors.