Aerodynamic characteristics of nebulized terbutaline sulphate using the Andersen Cascade Impactor compared to the Next Generation Impactor.

摘要

Characterization of the aerosol emitted from nebulizers is determined using the Next Generation Impactor (NGI). The Andersen Cascade Impactor (ACI) was previously used but the limitation of high flow rate used decreased its uses. We have investigated the use of ACI with different operational conditions compared to the NGI methodology. NGI was operated at a flow rate of 15?L min?1 after cooling at 5°C for 90?min. ACI was operated using flow rates 15 and 28.3?L min?1 at room (ROOM) temperature and after cooling at 5 °C for 60?min (COLD). ACI was also operated using a flow rate 15?L min?1 through the nebulizer T-piece with a flow rate 28.3?L min?1 through ACI (15 Mix) using the mixing valve at ROOM and COLD. Two nebulizer systems, the Sidestream (SIDE) and the Aeroneb Pro (AERO) were used to nebulize terbutaline sulphate respiratory solution. Overall there was a highly significant difference (P?