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首页> 外文期刊>Pharmaceutical Chemistry Journal >STRUCTURE OF CHEMICAL COMPOUNDS, METHODS OF ANALYSIS AND PROCESS CONTROL COMPARATIVE STUDY OF QUANTITATIVE DETERMINATION OF AMOXICILLIN IN CAPSULES BY MERCURIMETRY AND LIQUID CHROMATOGRAPHY
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STRUCTURE OF CHEMICAL COMPOUNDS, METHODS OF ANALYSIS AND PROCESS CONTROL COMPARATIVE STUDY OF QUANTITATIVE DETERMINATION OF AMOXICILLIN IN CAPSULES BY MERCURIMETRY AND LIQUID CHROMATOGRAPHY

机译:化学化合物的结构,分析方法和过程控制的比较研究—比色法和液相色谱法测定胶囊中阿莫西林的含量

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摘要

Assay of amoxicillin in capsules performed in accordance with the US Pharmacopeia by liquid chromatogra-phy was compared with a method based on mercurimetric titration, developed by ourselves, in which the internal indicator was an azo derivative of theophylline, i.e., benzenesulfonamide, N-(2,6-dimethoxy-4-pyrimi-dinyl)-4-[(4-methylamino-5-methylcarbamoyl)]azo2. The analysis results showed that mercurimetric assay was specific and easily performed in laboratory conditions and can be used as an alternative method.
机译:将根据美国药典通过液相色谱法测定的胶囊中阿莫西林含量与我们自行开发的基于汞滴定法的方法进行了比较,其中内部指示剂是茶碱的偶氮衍生物,即苯磺酰胺N-( 2,6-二甲氧基-4-嘧啶基)-4-[(4-甲基氨基-5-甲基氨基甲酰基)] azo2。分析结果表明,汞测定法是特异性的,可以在实验室条件下轻松进行,并且可以用作替代方法。

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