Children and adolescents with Type 1 diabetes with high VEGF have increased risk for cardiovascular disease

摘要

Children and adolescents with Type 1 diabetes and high levels of VEGF appear to be at an increased risk for cardiovascular disease. Previous studies have suggested that VEGF is an indicator of vascular tissue damage. The researchers recruited 105 children and adolescents, with an average age of 16.5 years, along with 30 healthy controls to asses the value of VEGF for estimating cardiovascular risk. Of the patients with Type 1 diabetes, a total of 16 had microalbuminuria (MA) or diabetic retinopathy (DR) and hypertension, and 74 did not. Levels of VEGF were found to be significantly higher in the MA/DR group with hypertension than in the controls and the non-MA/DR group. The results also showed that children and adolescents with Type 1 diabetes with no cardiovascular disease complications did not demonstrate significant results.