Children with autism often display difficult behaviors including tantrums, extreme irritability, and physical aggression. There is emerging evidence that olanzapine is useful in decreasing these disruptive behaviors. The most common adverse effects are weight gain and short-term sedation. On the other hand, olanzapine rarely causes rhabdomyolysis. We report a case with rhabdomyolysis in an autistic child just after 2 doses of olanzapine treatment. Initial creatine kinase value was 30,690 IU/L (range, 5-130 U/L), and rhabdomyolysis resolved with hydration and alkalinization over 7 days. Monitoring serum creatine kinase levels may be useful in pediatric cases after initiation of olanzapine treatment.
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机译：自闭症儿童经常表现出棘手的行为，包括发脾气，极度烦躁和身体攻击。越来越多的证据表明，奥氮平可用于减少这些破坏性行为。最常见的不良反应是体重增加和短期镇静。另一方面，奥氮平很少引起横纹肌溶解。我们报告了2剂奥氮平治疗后，一名自闭症儿童发生横纹肌溶解症的病例。最初的肌酸激酶值为30,690 IU / L（范围5-130 U / L），横纹肌溶解在7天内因水合和碱化而分解。在开始奥氮平治疗后，监测血清肌酸激酶水平可能对儿科患者有用。
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