Organophosphorus Esters of l-Hydroxy-2-phenylbenzimidazole: Synthesis and Utilization as Novel Peptide Coupling Reagents

摘要

Abstract: Highly efficient coupling reagents - phosphoric acid di-ethyl ester 2-phenylbenzimidazol-l-yl ester, diphenylphosphinic acid 2-phenylbenzimidazol-l-yl ester and phosphoric acid diphenyl ester 2-phenylbenzimidazol-l-yl ester-were designed, synthesized and successfully applied in peptide coupling reactions. Their efficiency was evaluated through the synthesis of a range of amides land peptides, and the extent of racemization was studied by HPLC and found to be negligible. The mechanism of action is probably similar to those found for organophoshorus esters of hydroxybenzotriazole: a presumption supported by the isolation and characterization by mass spectrometry and ~lH NMR of some of the proposed intermediates.