Improved synthesis of 1,3-propanediol derivatives having a diethoxyphosphoryldifluoroethyl functional group at the 2-position: Application to chemoenzymatic synthesis of novel acyclic nucleotide analogues of adenosine bisphosphates

摘要

An alternative synthesis of 1,3-propanediol 1 having a diethoxyphosphoryldifluoroethyl group was examined. The method readily provided a multi-gram quantity of 1. The propanediol 1 was chemo-enzymatically transformed to acyclic nucleotide analogues for adenosine bisphosphates.