Yb(OTf)(3)-catalyzed one-pot synthesis of quinazolin-4(3H)-ones from anthranilic acid, amines and ortho esters (or formic acid) in solvent-free conditions

摘要

An efficient synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, ortho esters (or formic acid) and amines using Yb(OTf)(3) in one-pot under solvent-free conditions is described. Compared with the classical reaction conditions, this new synthetic method has the advantage of excellent yields (75-99%), shorter reaction time (few minutes) and reusability of the catalyst. [References: 68]