SnCl2 · 2H2O-Catalyzed One-Pot Synthesis of 4(3H)-Quinazolinones from Anthranilic Acid, Ortho Esters,and Amines under Solvent Free Conditions

摘要

A simple, efficient, and green procedure for the one-pot synthesis of 4(3H)-quinazolinones by three components condensation of anthranilic acid, ortho esters, and amines in the presence of SnCl2 2H2O has been developed. The reaction occurred within short reaction time at room temperature under solvent- free conditions to afford the title products in excellent yields.