A total synthesis of 1-methoxycanthin-6-one: An efficient one-pot synthesis of the canthin-6-one skeleton from beta-carboline-1-carbaldehyde

摘要

A total synthesis of naturally occurring 1-methoxycanthin-6-one is described. In this synthesis, we achieved one-pot conversion from beta-carboline-1-carbaldehyde to the canthin-6-one skeleton by the sequential addition of lithium ketene acetal in LiHMDS solution followed by the addition of EtOH in the reaction mixture.