One-pot synthesis of Corey lactone in 150-minutes and totalsynthesis of latanoprost

摘要

Prostaglandins (PGs) are known to act as local hormones with the ability to control amultitude of important physiological properties.Some of their derivatives serve as usefulmedicines.For instance,latanoprost is a medication used in the treatment of glaucoma.Given the biological importance of PGs,the scientific community has invested a great dealof effort and ingenuity into their efficient synthesis.Corey's synthesis1 via the Corey lactoneis a landmark achievement,which greatly facilitated the science of PGs.