Anion-Stoichiometry-Dependent Selectivity Enhancement in Ion-Paired Chiral Ligand-Palladium Complex Catalyzed Enantioselective Allylic Alkylation

摘要

The ratio of chiral BrOnsted acid to ammonium-phosphine hybrid ligand in the in situ preparation of ion-paired chiral ligands was found to have a notable effect on the stereocontrolling ability of the corresponding palladium complex. The use of supramolecular palladium complexes generated from palladium metal, ammonium phosphine, and a chiral phosphoric acid in a ratio of 1:2:3 enabled an excellent level of enantiocontrol in the catalytic asymmetric allylation of -nitrocarboxylates with a functionalized allylic carbonate.