Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation

摘要

This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I):; comprising treating a compound of formula (II):; with a transition metal catalyst under alkylation conditions.