A convenient one-pot synthesis of spirocyclic pyrido[1,2-a]indole derivatives from 3-(2-bromoethyl)indole

摘要

A convenient one-pot approach for the synthesis of spirocyclic pyrido[1,2-a]indole derivatives is described. The method involves treatment of 1,3-diketones and 1,3-ketoesters with base to generate dianions, which react with 3-(2-broinoethyl)indole to construct a spirocyclopropyl ring and an N-heterocyclic ring sequentially in moderate to very good yields.