Palladium-catalyzed Michael addition of indoles to alpha,beta-unsaturated ketones in an ionic liquid

摘要

The PdCl2(CH3CN)(2)-catalyzed Michael addition reaction of indoles with alpha,beta-unsaturated ketones in ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]) to afford the corresponding 3-alkylated indoles in good yields is described. The catalyst system PdCl2(CH3CN)(2)/[bmim][BF4] can be recovered and reused.