A simple and efficient synthesis of N-[2-{(4-propionyloxyphenyl)thio}ethyl] propionamide (DIPCAP), a tyrosine-dependent cytotoxic agent as a topical antimelanoma therapy

摘要

The synthesis of N-[2-{(4-propionyloxyphenyl)thio}ethyl]propionamide (DIPCAP), a tyrosine-dependent cytotoxic agent that is currently being evaluated as a topical antimelanoma treatment is described. Problems encountered in scaling up the original patent procedure have been eliminated and DIPCAP was obtained in an overall yield of 65% from commercially available starting materials.