A novel synthetic approach from diosgenin to a 17alpha-hydroxy orthoester via a regio and stereo-specific rearrangement of an epoxy ester

摘要

A cholesterol model compound,containing 16beta-acetoxy,17alpha-hydroxy,and (20S,22R)-epoxy groups was synthesized from diosgenin in 13 steps and was rearranged regio-and stereo-specifically to an orthoester with BF_3·Et_2O.