SEMIPARAMETRIC LATENT VARIABLE TRANSFORMATION MODELS FOR MULTIPLE MIXED OUTCOMES

摘要

Technological advances that allow multiple outcomes to be routinely collected have brought a high demand for valid statistical methods that can summarize and study the latent variables underlying them. Outcome data with continuous and ordinal components present statistical challenges. We develop here a new class of semiparametric latent variable transformation models to summarize the multiple correlated outcomes of mixed types in a data-driven way. We propose a series of estimating equation-based and likelihood-based procedures for estimation and inference. The resulting estimators are shown to be n~(1/2)-consistent (even for nonparametric link functions) and asymptotically normal. Simulations suggest robustness as well as high efficiency, and the proposed approach is applied to assess the effectiveness of recombinant tissue plasminogen activator on ischemic stroke patients.