Biochemical changes in pancytopenic and non pancytopenic dogs with ehrlichiosis.

摘要

To study the biochemical changes in naturally infected dogs with Ehrlichia canis, blood samples from 57 animals were collected. Thirty-five healthy dogs were used as the control group. The mean serum protein, albumin, globulin, albumin:globulin ratio (A:G), urea, creatinine, alanine aminotransferase (ALT) and alkaline phosphatase (AP) levels in infected and control groups were determined and compared. The distribution of frequencies were also compared. Hypoproteinaemia, hypoalbuminaemia, decreased A:G ratio, hyperglobulinaemia, and uraemia were associated with ehrlichiosis (p<0.05). Regarding pancytopenia, it was observed that ALT and creatinine were the markers of ehrlichiosis in non-pancytopenic (NP) and pancytopenic (P) dogs. There were no significant differences in the protein profile of NP and P dogs, thus, supporting the presence of a marker for the disease.