Alcholic extracts of the red alga Acanthophora spicifera from the vicinity of Mandapam coast was tested for its tumoricidal effect in Ehrlich's ascites carcinoma cells developed in mice. Acanthophora spicifera exhibited tumoricidal activity at a doseof 20 mg/ kg b.w as compared to the standard drug, 5-flurouracil. This was evidenced by the increase in the mean survival time, decrease in tumor volume and viable cell count. The smear study exhibited membrane blebbing, vacuole formation and reduction in staining intensity, which further ascertained the tumoricidal activity.
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机译：测试了曼达帕姆海岸附近的红藻刺五加的醇提取物对小鼠中开发的Ehrlich腹水癌细胞的杀伤作用。与标准药物5-氟尿嘧啶相比，刺五加（Acanthophora spicifera）在20 mg / kg b.w的剂量下表现出杀肿瘤活性。平均生存时间增加，肿瘤体积减少和活细胞计数证明了这一点。涂片研究显示出膜起泡，液泡形成和染色强度降低，这进一步确定了其杀肿瘤活性。
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