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Concepts of Instability in Metastatic Disease of the Spine

机译:脊柱转移性疾病的不稳定性概念

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Cancer is the second leading cause of death in the United States.1 The proclivity for metastatic spread is a hallmark of this disorder and occurs in approximately two thirds of cancer patients. Metastases usually occur in the lung and liver and frequently involve the skeletal system. The spine is the most common site of skeletal metastasis.Over 80% of individuals who die with metastatic disease have documented spinal involvement.2 As the lesion expands, the triad of vertebral body destruction, instability, and neurological compromise occur. Effective treatment is largely dependent on early recognition of the disease and must employ a multidisciplinary approach involving surgeons, medical, and radiation oncologists.
机译:癌症是美国第二大死亡原因。1转移扩散的倾向性是该疾病的标志,大约三分之二的癌症患者中都发生过。转移瘤通常发生在肺和肝,并经常累及骨骼系统。脊柱是最常见的骨骼转移部位。死于转移性疾病的人中有80%以上已证明有脊柱受累。2随着病变的扩大,椎体破坏,不稳定性和神经功能受损的三联征发生。有效的治疗很大程度上取决于疾病的早期识别,并且必须采用涉及外科医师,医学和放射肿瘤学家的多学科方法。

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