Copper(II)complexes of the antihypertensive drug nadolol

摘要

The complexation of the non-selective beta-blocker nadolol,HL,1 with copper(II)leads to formation of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio.The mononuclear violet complex CuL_2·2Solv,2,was obtained in a soluble form at metal-to-ligand molar ratio Cu(II):HL<=1:10 in methanolic or slightly alkaline aqueous solutions.The dinuclear green complex Cu2L2Cl2·H2O,3 was synthesized at Cu(II):HL>=1:2 molar ratio in methanolic solutions.The complexes were studied using spectral(UV-Vis,FT-IR,EPR),magnetochemical,thermogravimetric methods and elemental analysis.In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II)through the NH-and the deprotonated OH-groups of its aminoalcohol fragment.