Dietary micronutrients and gastric cancer: Hospital based study

摘要

The association between micronutrients and gastric cancer is still unclear. The aim of this study is to determine the relationship between dietary intake of micronutrients and risk for gastric cancer. We used data from hospital-based case control study conducted at Clinical Centre Nis (Serbia) from 2005 and 2006. Patients (n=102) with first histologically confirmed gastric cancer and matched non-cancer patients (controls, n=204) were interviewed using structured questionnaire and FFQ (Food frequency questionnaire). Multivariate logistic regression analysis showed a significant positive association between gastric cancer and dietary intake of sodium (OR=6.22; 95%CI 1.99-7.86), but a significant negative association between potassium (OR 0.01; 95%CI 0.00-0.08), iron (OR 0.05; 95%CI 0.01-0.56), vitamin C (OR 0.05; 95%CI 0.01-0.38), vitamin E (OR 0.04; 95%CI 0.01-0.29) and niacin (OR 0.07; 95%CI 0.00-0.38) dietary intake. Intake of phosphorus, calcium, magnesium, zinc, retinol, β carotene, tiamin, vitamin B6, and folic acid was not significantly related to gastric cancer risk. In conclusion, we found that a dietary pattern of high consumption of antioxidants (vitamin C, vitamin E, niacin), iron and potassium and low consumption of foods that are sources of sodium, decreased risk for gastric cancer. Our results require confirmation in future studies.