ENVIRONMENTAL RISK ASSESSMENT OF BISPHENOL A AND ITS METABOLITES AS ENDOCRINE DISRUPTORS

摘要

One of chemical found ubiquitously in our environment, bisphenol A (BPA), has received a tremendous amount of attention from research scientists, government panels, and the popular press. Understanding this topic is essential for educating the public professionals about potential risks associated with developmental exposure to BPA and other endocrine disrupters, the design of rigorously researched programs using both epidemiological and animal studies, and ultimately the development of a public health policy. The aim of this work was to predict risk assessment (persistence, bioaccumula-tion and chronic toxicity) of bisphenol A (parent structure) and its microbial metabolites (observed and predicted) using the QSAR models in the PBT Profiler and in addition to predict the estrogenic activity of the parent structure and metabolites of bisphenol A by the OECD (Q)SAR Application Toolbox. The estrogenic activity of the parent structure (bisphenol A) was predicted to be very strong binder by the OECD (Q)S AR Application Toolbox and the PBT Profiler has estimated that bisphenol A is persistent in the environment, is not expected to bioaccumulate in the food chain, and is chronic toxic (moderate concern). Analysis of the data reveals that the estrogenic activity of observed metabolites of bisphenol A is varied (non-cyclic structure, weak, strong and very strong binder) and for predicted metabolites of bisphenol A is non-cyclic structure and weak binder. All observed and predicted (with few exceptions) metabolites are persistent in the environment but they are not bioaccumulative. More observed metabolites are chronically toxic (high, moderate and low concern) and the toxic behaviour of predicted metabolites of bisphenol A is varied (high, moderate and low concern).