EVALUATION OF ANTIMICROBIAL ACTIVITY AND QSAR STUDY OF A MOLECULE LIBRARY OF THE MANNICH BASES OF GLUTARIMIDES

摘要

Forty amino-alkylated Mannich bases of various glutarimides with intact imide moiety are synthesised for the first time from various sulphonamides and secondary amines. The structural characterisation is made using elemental and spectral studies. QSAR studies revealed that out of the large pool of topological indices and molecular descriptor used some topological indices are more useful for modelling antimicrobial activity against 6 bacteria: B. subtilis, S. typhi, E. coli, S. aureus, K. pneumoniae and P. aeruginosa. The Mannich bases are found more potent than their parent sulphonamides. The results are discussed critically using a variety of statistical parameters.