A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON A SERIES OF 4,1-BENZOXAZEPINONE ANALOGUES OF EFAVIRENZ, AS HIV-1 REVERSE TRANSCRIPTASE INHIBITORS

摘要

The anti HIV-1 activity of benzoxazepinone analogues of Efavirenz is analysed in relation to their physicochemical and molecular properties. The activity of the compounds is found to be significantly correlated with steric parameter, molecular connectivity ~1χ~v and lg I, electronic parameter, equalised electro-negativity χ_(eq) and hydrophobicity lg P. The results are found to be useful in discussing the mechanism of drag receptor interaction.