α-Regioselective [3 + 2] annulations with Morita-Baylis-Hillman carbonates of isatins and 2-nitro-1,3-enynes

摘要

An α-regioselective asymmetric [3 + 2] annulation reaction with Morita-Baylis-Hillman carbonates of isatins and (E)-2-nitro-1,3-enynes catalysed by cinchona-derived amines has been developed, providing spirooxindoles with contiguous chiral centres including adjacent quaternary ones in moderate to good yields with high enantioselectivity and excellent diastereoselectivity.