Synthesis of medium-sized cyclic amines by selective ring cleavage of sulfonylated bicyclic amines

摘要

An efficient method of synthesis of functionalized medium-sized cyclic amines (eitht-to ten-membered rings) by selective ring opening of sulfonylated bicyclic pyrrolizidine,indolizidine,and quinolizidine compounds is described.The key step is the selective cleavage of the central C-N bond of the bicyclic amine bymeans of a Julia-like desulfonylation process.