Highly Regio- and Enantioselective Heck Reaction of N-Methoxycarbonyl-2-pyrroline with Planar Chiral Diphosphine-oxazoline Ferrocenyl Ligands

摘要

A series of planar chiral diphosphine-oxazoline ferrocene ligands were effectively applied in the asymmetric arylation of N-methoxycarbonyl-2-pyrroline, and up to 99% ee was observed for the product 3. The regioselectivity of this reaction was strongly affected by the different precursors of the palladium species and the polarity of the solvent.