Cu(I)-catalyzed enantioselective [3+2] cycloaddition reaction of 1-alkylallenylsilane with alpha-imino ester: Asymmetric synthesis of dehydroproline derivatives

摘要

The catalytic, enantioselective [3 + 2] cycloaddition reaction of 1-alkyl-substituted allenylsilanes with alpha-imino ester has been achieved by means of [Cu(MeCN)(4)]BF4/(R)-DM-SEGPHOS catalyst to afford silyl-substituted dehydroproline derivatives in high yields and enantioselectivities.