An efficient one pot synthesis of Dibenzo [b, f] thiazepin-ll[10H]-one: A key intermediate for synthesis of Quetiapine an antipsychotic drug

摘要

An efficient one pot synthetic pathway is described for Dibenzo [b, f] thiazepin-11[10H]-one, a key intermediate in the synthesis of Quetiapine. The procedure starts from 1-chloro-2-nitrobenzene and involves five simple insitu steps in one pot to give Dibenzo [b, f] thiazepin-11[10H]-one in 70% overall yield with >99% purity.