A key intermediate of natural compound diazepinomicin, 4,6,8-trimethoxy-5H-dibenzo[b, e][l ,4] diazepinll( 10/0-one, was synthesized from 2,4-dimethoxyaniline and 3-methylphenol by amino-protection, niration, reduction, oxidation, intermolecular Ullmann reaction and lactamization. The structrue was characterized by 1H NMR, IR and MS.%以2,4-二甲氧基苯胺和3-甲基苯酚为原料,通过氨基保护、硝化、还原、甲基氧化、乌尔曼反应、内酰胺环化制得天然化合物Diazepinomicin的关键中间体——三甲氧基二苯二氮平,其结构经1H NMR,IR和MS表征.
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