Hypoxia-induced epithelial-mesenchymal transition is regulated by phosphorylation of GSK3-beta via PI3 K/Akt signaling in oral squamous cell carcinoma

Kaneko Takeshi; Dehari Hironari; Sasaki Takanori; Igarashi Tomohiro; Ogi Kazuhiro; Okamoto Jun-ya; Kawata Mayumi; Kobayashi Jun-ichi; Miyazaki Akihiro; Nakamori Kenji; Hiratsuka Hiroyoshi

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Hypoxia-induced epithelial-mesenchymal transition is regulated by phosphorylation of GSK3-beta via PI3 K/Akt signaling in oral squamous cell carcinoma

机译：缺氧诱导的上皮-间质转化受口腔鳞状细胞癌中PI3K / Akt信号转导的GSK3-β磷酸化的调控

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Objective. Epithelial-mesenchymal transition (EMT) plays an important role in cancer invasion and metastasis induced by hypoxia. Here, we examined whether phosphorylation of GSK3-beta via phosphoinositide 3-kinase (PI3 K)/Akt signaling is involved in enhancing the hypoxia-induced EMT in oral squamous cell carcinoma (OSCC).

机译：目的。上皮-间质转化（EMT）在缺氧诱导的癌症侵袭和转移中起重要作用。在这里，我们检查了是否通过磷酸肌醇3激酶（PI3 K）/ Akt信号转导GSK3-β的磷酸化与增强口腔鳞状细胞癌（OSCC）缺氧诱导的EMT有关。

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《Oral surgery, oral medicine, oral pathology oral radiology》 |2016年第6期|共12页
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Kaneko Takeshi; Dehari Hironari; Sasaki Takanori; Igarashi Tomohiro; Ogi Kazuhiro; Okamoto Jun-ya; Kawata Mayumi; Kobayashi Jun-ichi; Miyazaki Akihiro; Nakamori Kenji; Hiratsuka Hiroyoshi;
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1. Hypoxia-induced epithelial-mesenchymal transition is regulated by phosphorylation of GSK3-beta via PI3 K/Akt signaling in oral squamous cell carcinoma [J] . Kaneko Takeshi, Dehari Hironari, Sasaki Takanori, Oral surgery, oral medicine, oral pathology oral radiology . 2016,第6期

机译：缺氧诱导的上皮-间质转化受口腔鳞状细胞癌中PI3K / Akt信号转导的GSK3-β磷酸化的调控
2. Activation of PI3 kinase/Akt/HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma [J] . Min Jiao, Ke-Jun Nan International journal of oncology . 2011,第2期

机译：PI3激酶/ Akt /HIF-1α途径的激活有助于缺氧诱导的肝细胞癌上皮-间质转化和化学耐药性
3. PI3 kinase/Akt signaling mediates epithelial-mesenchymal transition in hypoxic hepatocellular carcinoma cells. [J] . Yan W, Fu Y, Tian D, Biochemical and Biophysical Research Communications . 2009,第3期

机译：PI3激酶/ Akt信号传导介导低氧肝细胞癌细胞的上皮-间质转化。
4. PLK1 Promotes Invasion of Esophageal Squamous Cell Carcinoma Cells through Inducing Epithelial-mesenchymal Transition [C] . Jiyu Ju, Wenjing Yu, Chunling Zhao International Conference on Applied Sciences, Engineering and Technology . 2014

机译：PLK1通过诱导上皮 - 间充质转换来促进食管鳞状细胞癌细胞的侵袭
5. Effects of isoflavones and glycolytic enzyme inhibitors on regulation of proliferation and signaling pathways in oral squamous cell carcinoma cells (SCC15, SCC25): A mechanistic study [D] . Johnson, Tara Bardsley 2007

机译：异黄酮和糖酵解酶抑制剂对口腔鳞状细胞癌细胞（SCC15，SCC25）增殖和信号通路的调节作用的机理研究
6. Activation of PGK1 under hypoxic conditions promotes glycolysis and increases stem cell-like properties and the epithelial-mesenchymal transition in oral squamous cell carcinoma cells via the AKT signalling pathway [O] . Yadong Zhang, Hongshi Cai, Yan Liao, -1

机译：在缺氧条件下激活PGK1促进糖酵解并通过Akt信号通路在口腔鳞状细胞癌细胞中增加干细胞样性能和上皮 - 间充质转变
7. Activation of PI3 kinase/Akt/HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma [O] . Ke-Jun Nan 2011

机译：PI3激酶/ AKT / HIF-1α途径的激活有助于缺氧诱导的肝细胞癌中的上皮 - 间充质转换和化学抑制剂

Hypoxia-induced epithelial-mesenchymal transition is regulated by phosphorylation of GSK3-beta via PI3 K/Akt signaling in oral squamous cell carcinoma

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