Among the dietary strategies to overcome adiposity and obesity, the omission of carbohydrates in low-carbohydrate, high-fat diets (LC-HFDs) has been proposed as a tool for weight loss [1]. Popular weight loss guidebooks, including the Atkins diet books [2], claim that the lack of carbohydrates in LC-HFDs always triggers ketosis which would contribute to the weight-reducing effects of these diets. However, this theory was widely criticized in literature. Apart from attempts to reduce body weight with LC-HFDs, ketogenic LC-HFDs are also used to intentionally induce ketosis in patients with epilepsy and lately also as a potential beneficial treatment in other neurological diseases such as Alzheimer's and Parkinson's disease [3]. Both indications to use LC-HFDs are subject to intense research including rodent models.
展开▼
