Effector memory regulatory T-cell expansion marks a pivotal point of immuneescape in myelodysplastic syndromes.

摘要

Myleodysplastic syndromes (MDS) are pre-malignant hematopoietic diseases that canprogress to acute myeloid leukemia (AML) progression in conjunction with changes in immune function. In this model of leukemia evolution, the expansion ofimmunosuppressive regulatory T cells (Tregs) contributes to immune escape. Here, we discuss the importance of Treg-memory phenotype switching as a poor prognosticindicator in MDS.