The majority of rodent and human tumors express antigens that can be recognizedby T lymphocytes and are infiltrated by immune cells. Although tumor infiltrationby T lymphocytes has been associated with a favorable prognosis, the role ofdendritic cells (DCs), which may present tumor-associated antigens in animmunogenic or tolerogenic context, remains elusive. Here, we discuss recentobservations suggesting that the function of DCs in the tumor microenvironmentmay impact the spontaneous resistance of neoplasms to chemotherapy as well astreatment outcome.
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