MAF drives CD8(+) T-cell exhaustion

摘要

The molecular regulation of tumor induced T-cell exhaustion remains poorly characterized. Recently, we compared the transcriptome of "exhausted" CD8(+) T cells infiltrating melanomas to those of naive and acutely stimulated CD8(+) T cells. We demonstrated that MAF is over-expressed and plays a key role in driving the transcriptional program of T-cell exhaustion.