IgG4 antibodies and cancer-associated inflammation: Insights into a novelmechanism of immune escape.

摘要

The role of B cells and antibodies in cancer is insufficiently understood but is receiving increasing attention. We have recently identified IgG4 as an antibodysubclass elicited by melanoma-associated interleukin-10-driven inflammation. Inthis setting, IgG4 exhibit inefficient immunostimulatory capacity and block thecytotoxic activities of other antibodies. These previously unappreciatedmechanisms of immune escape may constitute promising targets for the development of novel anticancer immunotherapies.