Dipolar Cycloaddition of N-Aryl-C-(2,2-dichloro-1-phenyl-eyclopropyl)nitrones to N-Arylmaleimides

摘要

1,3-Dipolar cycloaddition of N-aryl-C-(2,2-dichloro-1-phenylcyclopropyl)nitrones to N-arylmale-imides stereoselectively gives substituted pyrrolo[3,4-d]isoxazolidines as mixtures of two diastereoisomers differing by configuration at the C~1 atom of the cyclopropane ring in the substituent on C~3. Substituents in the aromatic rings of the initial nitrone and maleimide do not affect the stereochemistry of the process.