Convenient Synthesis of a New Class of Chiral Hydroxymethyl-dihydrooxazole Ligands and Their Application in Asymmetric Addition of Diethylzinc to Aromatic Aldehydes

摘要

A number of chiral hydroxymethyl-substituted dihydrooxazoles were synthesized from D- or L-mandelic acid and amino alcohols.The chiral ligands thus obtained were tested as catalyst in the asymmetric addition of diethylzinc to aromatic aldehydes,and the structure-activity relationship was studied.The addition products were characterized by an enantiomeric excess of up to 91%.