CHIRAL LIGANDS DERIVED FROM ABRINE .3. ASYMMETRIC PICTET-SPENGLER REACTION OF ABRINE METHYL ESTER AND SYNTHESIS OF CHIRAL 1,2,3,4-TETRAHYDRO-BETA-CARBOLINES AS PROMOTERS IN ADDITION OF DIETHYLZINC TOWARD AROMATIC ALDEHYDES

摘要

Asymmetric Pictet-Spengler reaction of a number of aldehydes with Abrine methyl ester (1) was performed at room temperature to furnish mainly 3 and high ee was obtained in enantioselective addition of Et(2)Zn with PhCHO catalyzed by chiral 1,2,3,4-tetrahydro-beta-carboline derivatives 5 synthesized from 3. Copyright (C) 1996 Elsevier Science Ltd [References: 41]