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APPLICATION OF CHIRAL AMINOPHENOL LIGAND IN ASYMMETRIC SYNTHESIS OF EFAVIRENZ
APPLICATION OF CHIRAL AMINOPHENOL LIGAND IN ASYMMETRIC SYNTHESIS OF EFAVIRENZ
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机译:手性氨基酚配体在非对称合成依法维仑中的应用
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摘要
The present invention relates to an application of a chiral aminophenol ligand in asymmetric synthesis of efavirenz. A chiral aminophenol ligand compound is used for inducing asymmetric synthesis of (S) 6 chloro 4 cyclopropylethynyl 4 trifluoromethyl 1 4 dihydro 2H 1 3 benzoxazine 2 ketone (efavirenz). The ligand is cheap easily available safe and recoverable is used in asymmetric synthesis of efavirenz and has the advantages of high yield good enantioselectivity simplicity and convenience in operation capability of realizing industrialized production and good product quality.
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