Synthesis and Structure of Fluoroalkyl Containing Lithium 1,3-Diketonates

摘要

Methods of synthesis and IR, mass, NMR ~1H, ~(19)F, ~(13)C spectra as well as X-ray analysis of fluoroalkyl containing lithium 1,3-diketonates are reviewed. Fluoroalkyl containing lithium 1,3-diketonates (P-di-ketonates) proved themselves to be promising poly-functional reagents [1-14]. They are more accessible than corresponding 1,3-diketones and react with mono-and binucleophilic agents, and also enter tandem A_N-A_Nr reactions of diaddition to π-deficit azines, which allows various polyfunctional aliphatic compounds to be obtained on their basis (1,3-diketones and their complexes with metals, 1,3-hydroxyketones, region-isomeric enaminoketones) [1-5] and also heterocyclic systems (derivatives of isoxazole, pyrazole, diazepine, pyrimidine, quinoline, phenanthridine, quinazoline, pyridazine, and cinnoline) [1, 2, 6-14].In the majority of processes lithium 1,3-diketonates as reagents are equivalent to corresponding diketones. But there are examples of specific reactivity of 1,2-diketonates showing itself even in the reactions occurring in the medium of glacial acetic acid, when corresponding 1,3-diketone is generated in situ [1-14].