Synthesis of Novel Substituted Pyridines from 1-(3-Aminophenyl)-3-(1H-indol-3-yl)prop-2-en-1-one and Their Anticancer Activity

摘要

A series of novel substituted pyridine derivatives have been synthesized via the reaction of 3-indole carboxaldehyde with 3-aminoacetophenone. The products structures have been elucidated from elemental analysis as well as IR, H-1 NMR, C-13 NMR, and MS spectroscopy data. All the synthesized compounds have shown anticancer activity against HEPG2 and MCF-7 in vitro; some of them have exhibited the in vivo activity.