Synthesis of Novel 1-(4-Substituted pyridine-3-sulfonyl)-3-phenylureas with Potential Anticancer Activity

摘要

A series of novel 4-substituted-N-(phenylcarbamoyl)-3-pyridinesulfonamides >11–>27 have been synthesized by the reaction of 4-substituted pyridine-3-sulfonamides >2–>10 with the appropriate aryl isocyanates in presence of potassium carbonate. The in vitro anticancer activity of compounds >11, >12, >14–>21 and >24–>26 was evaluated at the U.S. National Cancer Institute and in light of the results, some structure-activity relationships were discussed. The most prominent compound, N-[(4-chlorophenyl)carbamoyl]-4-[4-(3,4-dichlorophenyl)piperazin-1-yl]pyridine-3-sulfonamide (>21) has exhibited a good activity profile and selectivity toward the subpanels of leukemia, colon cancer and melanoma, with average GI50 values ranging from 13.6 to 14.9 µM.