Calix[4]arenes Containing Benzodiazepinone Fragments at the Lower Rim

摘要

A series of p-tert-butylcalix[4]arene derivatives containing 1,4(1,5)-benzodiazepinone fragments as substituents were prepared.The biological activity of the compounds,namely,their antispasmodic activity in mice,was evaluated by antagonism with a spasmodic agent,Corazol,upon transdermal administration.According to the data obtained,benzodiazepine derivatives of calixarenes show higher antispasmodic activity compared to 3-hydroxyphenazepam,taking into account their considerably higher molecular weight.